Glycans in Diseases & Therapeutics

Glycomedicine plays major role in cell-cell adhesion i.e. a mechanism employed by cells of the immune system via sugar-binding proteins called lectins, which recognize specific carbohydrate moieties. Glycans (carbohydrate oligomers) are the “building blocks” of carbohydrates, nucleic acids, proteins and lipids which play major roles in many biological phenomena as well as in various pathophysiological processes. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology or glycochemistry approach to be used.

 

  • Congenital disorders of glycosylation (CDG)
  • Transfusion medicine
  • Glycomedicine
  • Cardiac arrest
  • Cancer associated coagulopathies
  • Cardiovascular diseases
  • Cancer biomarkers

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