Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 10th Glycobiology World Congress Vienna, Austria.

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Scientific Program Day 1

Day 1 :

  • Glycochemistry

Session Introduction

Sang-Il Han

Korea University, Korea

Title: Effect of Pseudoalteromonas sp. MEBiC 03485 on Biomass Production and Sulfated Extracellular Polysaccharide Biosynthesis of Porphyridium cruentum UTEX 161
Speaker
Biography:

Sang-Il Han is a PhD student at Korea University. He is mainly studying the industrial use of microalgae and their secondary metabolites. He has published 9 papers in SCI(E) journals and KCI journals

Abstract:

Porphyridium cruentum is an industrially valuable red microalga (Rhodophyta) that can produce rich amounts of sulfated extracellular polysaccharides (S-EPS). However, the industrial application of the P. cruentum is limited, and it is mostly hindered by low yield that does not meet the demand for commercial production. Therefore, we attempted to develop a novel strategy based on microbial interactions to enhance P. cruentum EPS production and biomass. In this study, the effect of co-culturing Pseudoalteromonas sp. MEBiC 03485 with P. cruentum UTEX 161 were examined. Pseudoalteromonas sp. enhanced the growth of P. cruentum and the productivity and biological activities of S-EPS. The biological activities of S-EPS extracts from the P. cruentum culture treated with Pseudoalteromonas sp. were higher than the negative control. These results were due to the compounds secreted from Pseudoalteromonas sp., which stimulated the production of phycoerythrin and phycocyanin, thus eventually increasing the growth of P. cruentum as well as the productivity and the sulfur content of the S-EPS. Our results suggest a novel approach for potentially enhancing the growth of P. cruentum and the productivity and bioactivities of the S-EPS by co-culturing with the symbiotic bacterium Pseudoalteromonas sp. MEBiC 03485. 

Zeynep Dilek HEPERKAN

Istanbul Aydın University, Turkey

Title: Producing dextran from Weissella confusa on solid media and examining the fate of Weissella confusa during fermentation
Biography:

Abstract:

Martin Götte

University of Munster, Germany

Title: The heparan sulfate proteoglycan Syndecan-1 and heparanase are novel regulators of cancer stem cell function and therapeutic resistance
Speaker
Biography:

Martin Götte is a Professor for Medical Biochemistry at the Department of Gynecology and
Obstetrics of the University of Münster, Germany. He obtained his diploma (Biology) in 1994 at the
University of Münster, and his Ph.D. (Biochemistry) in 1997 from the University of Göttingen
and the Max-Planck-Institute for Biophysical Chemistry. After a postdoctoral research period in
Merton Bernfields Laboratory at Harvard Medical School, Boston USA, he became a group
leader in Hans Kresses laboratory at the Institute of Physiological Chemistry of Münster
University. Since 2003, he holds a tenured position as head of the research laboratory of the
Department of Gynecology and Obstetrics of Münster University.

Abstract:

The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix
components, regulating cancer stem cell properties and invasiveness. Syndecan-1 is modulated by
the heparan sulfate-degrading enzyme heparanase, but the underlying regulatory mechanisms are
only poorly understood (1). In colon cancer pathogenesis, complex changes occur in the expression
pattern of Syndecan-1 and heparanase during progression from well-differentiated to
undifferentiated tumors. Loss of Syndecan-1 and increased expression of heparanase are associated
with a change in phenotypic plasticity and an increase in invasiveness, metastasis and
dedifferentiation. Here we investigated the regulatory and functional interplay of Syndecan-1 and
heparanase employing siRNA-mediated silencing and plasmid-based overexpression approaches in
human colon cancer cell lines and in a xenograft model (2,3). Sdc-1 small-interfering RNA knockdown
in the human colon cancer cell lines Caco2 and HT-29 resulted in an increased side population (SP),
enhanced aldehyde dehydrogenase 1 activity, and higher expression of CD133,CD133, LGR5, EPCAM,
NANOG, SRY (sex-determining region Y)-box 2, KLF2, and TCF4/TCF7L2.